A Review on
نویسندگان
چکیده
Introduction: Imidazole is an entity which is being synthesized in many of its derivative form from past few years; the entity is major source of interest for many of medicinal chemist to explore its various pharmacological potentials. In present article we review the chemistry of imidazole and its pharmacological actions as antihelmintics, anticancer, antifungal and anti-inflammatory agent by studying its various synthesized derivatives. Material and method: literature study of various research papers and other publications which provide detailed work on chemistry of the imidazole and its various pharmacological actions by synthesizing its different derivatives. Result: Present data suggests that imidazole being hetero-atomic planar five-member ring system have diverse chemistry with varying physical and chemical properties which may be exploited via forming various derivatives having varying pharmacological actions. Results of various combinations of different moieties with imidazole and their substitutions are reviewed in present article. Conclusion: Various methods for synthesizing imidazoles are discussed with their chemistry. Studying this chemistry different substituted and fused compounds of imidazole are analyzed here for varying pharmacological activities.
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